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Article

Gab1, SHP2, and protein kinase A are crucial for the activation of the endothelial NO synthase by fluid shear stress.

Circulation research - 9 Dec 2005

Dixit Madhulika, Loot Annemarieke E, Mohamed Annisuddin, Fisslthaler Beate, Boulanger Chantal M, Ceacareanu Bogdan, Hassid Aviv, Busse Rudi, Fleming Ingrid

Abstract excerpt

Fluid shear stress enhances NO production in endothelial cells by a mechanism involving the activation of the phosphatidylinositol 3-kinase and the phosphorylation of the endothelial NO synthase (eNOS). We investigated the role of the scaffolding protein Gab1 and the tyrosine phosphatase SHP2 in this signal transduction cascade in cultured and native endothelial cells. Fluid shear stress elicited the...

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Identifiers

PMID: 16284184
DOI: 10.1161/01.RES.0000195611.59811.ab

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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