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Article

Fluid Shear Stress Modulation of Gene Expression in Endothelial Cells

1 Oct 1998

Abstract excerpt

The vascular endothelium, lining the blood vessel wall, is constantly exposed to wall shear stresses generated by flowing blood. Gene regulation, critical for endothelial cell function, depends on complex interactions at the promoter level and utilizes overlapping signal transduction cascades to activate the expression of genes involved in many biological processes.

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Identifiers

PMID: 11390796
DOI: 10.1152/physiologyonline.1998.13.5.241

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