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Article

MicroRNAs in flow-dependent vascular remodelling.

Cardiovascular research - 15 Jul 2013

Neth Peter, Nazari-Jahantigh Maliheh, Schober Andreas, Weber Christian

Abstract excerpt

Changes in haemodynamic forces in the vascular system result in an altered expression of miRs, which play important gene-regulatory roles by pairing to the mRNAs of protein-coding genes to fine-tune post-transcriptional repression. The development and structure of blood vessels are highly adapted to haemodynamic forces, such as shear stress, cyclic stretch, and circumferential wall stress, generated by the...

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Identifiers

PMID: 23612583
DOI: 10.1093/cvr/cvt096

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