Article
ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4.
Circulation research - 28 Apr 2017
Choi Dongwon, Park Eunkyung, Jung Eunson, Seong Young Jin, Hong Mingu, Lee Sunju, Burford James, Gyarmati Georgina, Peti-Peterdi Janos, Srikanth Sonal, Gwack Yousang, Koh Chester J, Boriushkin Evgenii, Hamik Anne, Wong Alex K, Hong Young-Kwon
Abstract excerpt
RATIONALE: Lymphatic vessels function to drain interstitial fluid from a variety of tissues. Although shear stress generated by fluid flow is known to trigger lymphatic expansion and remodeling, the molecular basis underlying flow-induced lymphatic growth is unknown. OBJECTIVE: We aimed to gain a better understanding of the mechanism by which laminar shear stress activates lymphatic proliferation. METHODS AND...
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