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Article

PCNA binding domains in all three subunits of yeast DNA polymerase δ modulate its function in DNA replication.

Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 2011

Acharya Narottam, Klassen Roland, Johnson Robert E, Prakash Louise, Prakash Satya

Abstract excerpt

DNA polymerase δ (Polδ) plays an essential role in replication from yeast to humans. Polδ in Saccharomyces cerevisiae is comprised of three subunits, the catalytic subunit Pol3 and the accessory subunits Pol31 and Pol32. Yeast Polδ exhibits a very high processivity in synthesizing DNA with the proliferating cell nuclear antigen (PCNA) sliding clamp; however, it has remained unclear how Polδ binds PCNA to achieve...

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Source

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Identifiers

PMID: 22003126
DOI: 10.1073/pnas.1109981108
PMCID: PMC3207673

Genes

PCNA
PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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PCNA binding domains in all three subunits of yeast DNA polymerase δ modulate its function in DNA replication.PMID 22003126Read ↗

Evidence for a functional interaction between yeast Pol ε and PCNA in vivo.Semantic proximity Read ↗

Identification of PCNA interacting protein motifs in human DNA polymerase deltaSemantic proximity Read ↗

A four-subunit DNA polymerase ζ complex containing Pol δ accessory subunits is essential for PCNA-mediated mutagenesis.Semantic proximity Read ↗

The Pol32 subunit of DNA polymerase delta contains separable domains for processive replication and proliferating cell nuclear antigen (PCNA) binding.Semantic proximity Read ↗

Phosphorylation of the p68 subunit of Pol δ acts as a molecular switch to regulate its interaction with PCNA.Semantic proximity Read ↗

The non-canonical protein binding site at the monomer-monomer interface of yeast proliferating cell nuclear antigen (PCNA) regulates the Rev1-PCNA interaction and Polζ/Rev1-dependent translesion DNA synthesis.Semantic proximity Read ↗

Proficient Replication of the Yeast Genome by a Viral DNA Polymerase.Semantic proximity Read ↗

Stable interactions between DNA polymerase δ catalytic and structural subunits are essential for efficient DNA repair.Semantic proximity Read ↗

Mismatch repair operates at the replication fork in direct competition with mismatch extension by DNA polymerase δ.Semantic proximity Read ↗

The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ.Semantic proximity Read ↗

Limiting DNA polymerase delta alters replication dynamics and leads to a dependence on checkpoint activation and recombination-mediated DNA repairSemantic proximity Read ↗

Different types of interaction between PCNA and PIP boxes contribute to distinct cellular functions of Y-family DNA polymerases.Semantic proximity Read ↗

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