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Article

Ubiquitin mediates the physical and functional interaction between human DNA polymerases η and ι.

Nucleic acids research - 1 Feb 2013

McIntyre Justyna, Vidal Antonio E, McLenigan Mary P, Bomar Martha G, Curti Elena, McDonald John P, Plosky Brian S, Ohashi Eiji, Woodgate Roger

Abstract excerpt

Human DNA polymerases η and ι are best characterized for their ability to facilitate translesion DNA synthesis (TLS). Both polymerases (pols) co-localize in 'replication factories' in vivo after cells are exposed to ultraviolet light and this co-localization is mediated through a physical interaction between the two TLS pols. We have mapped the polη-ι interacting region to their respective ubiquitin-binding...

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Source

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Identifiers

PMID: 23248005
DOI: 10.1093/nar/gks1277
PMCID: PMC3561947

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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