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Article

DNA polymerase eta lacking the ubiquitin-binding domain promotes replicative lesion bypass in humans cells.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jun 2010

Acharya Narottam, Yoon Jung-Hoon, Hurwitz Jerard, Prakash Louise, Prakash Satya

Abstract excerpt

The Rad6-Rad18 mediated monoubiquitylation of proliferating cell nuclear antigen (PCNA) at lys 164 plays a crucial role in promoting the access of translesion synthesis (TLS) DNA polymerases (Pols) to PCNA in the replication fork stalled at a lesion site. Although a number of genetic and biochemical observations have provided strong evidence that TLS Pols bind PCNA at its interdomain connector loop (IDCL) via...

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Source

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Identifiers

PMID: 20498091
DOI: 10.1073/pnas.1005492107
PMCID: PMC2890850

Genes

PCNA
PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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DNA polymerase eta lacking the ubiquitin-binding domain promotes replicative lesion bypass in humans cells.PMID 20498091Read ↗

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Interaction with DNA polymerase eta is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells.Semantic proximity Read ↗

Mutations in the ubiquitin binding UBZ motif of DNA polymerase eta do not impair its function in translesion synthesis during replication.Semantic proximity Read ↗

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