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Article

Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice.

PloS one - 1 Jan 2014

Krohn Jon, Speed Doug, Palme Rupert, Touma Chadi, Mott Richard, Flint Jonathan

Abstract excerpt

The extent to which sex-specific genetic effects contribute to phenotypic variation is largely unknown. We applied a novel Bayesian method, sparse partitioning, to detect gene by sex (GxS) and gene by gene (GxG) quantitative loci (QTLs) in 1,900 outbred heterogeneous stock mice. In an analysis of 55 phenotypes, we detected 16 GxS and 6 GxG QTLs. The increase in the amount of phenotypic variance explained by...

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Identifiers

PMID: 24811081
DOI: 10.1371/journal.pone.0096450
PMCID: PMC4014490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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