Back to search

Article

Genetic factors contributing to extensive variability of sex-specific hepatic gene expression in Diversity Outbred mice

2020-06-29

Abstract excerpt

Sex-specific transcription characterizes hundreds of genes in mouse liver, many implicated in sex-differential drug and lipid metabolism and disease susceptibility. While the regulation of liver sex differences by growth hormone-activated STAT5 is well established, little is known about autosomal genetic factors regulating the sex-specific liver transcriptome. Here we show, using genotyping and expression data fro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
60466684-2419-5634-a699-51d6f50e48bb
DOI
10.1101/2020.06.29.177311
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Genetic factors contributing to extensive variability of sex-specific hepatic gene expression in Diversity Outbred miceDOI 10.1101/2020.06.29.177311
Genetic factors contributing to extensive variability of sex-specific hepatic gene expression in Diversity Outbred mice.Semantic proximity
Harnessing natural variation to identify <i>cis</i> regulators of sex-biased gene expression in a multi-strain mouse liver modelSemantic proximity
Harnessing natural variation to identify cis regulators of sex-biased gene expression in a multi-strain mouse liver model.Semantic proximity
Sex-biased long non-coding RNAs negatively correlated with sex-opposite protein coding gene co-expression networks in Diversity Outbred mouse liverSemantic proximity
Transcriptional Profiling of Human Liver Identifies Sex-Biased Genes Associated with Polygenic Dyslipidemia and Coronary Artery DiseaseSemantic proximity
Sexual Dimorphism in Gene Expression: A Multi-Tissue Genome-Wide Study in BXD Mice and Potential Insights into Human BiologySemantic proximity
The Effects of Sex and Diet on Physiology and Liver Gene Expression in Diversity Outbred MiceSemantic proximity
Sex-specific gene expression in the BXD mouse liverSemantic proximity
Sexual Dimorphism in Gene Expression: A Genome-Wide Study of Tissue and Chromosome DependenciesSemantic proximity
Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity.Semantic proximity
Relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in tissue gene regulationSemantic proximity
Dynamic, Sex-Differential STAT5 and BCL6 Binding to Sex-Biased, Growth Hormone-Regulated Genes in Adult Mouse LiverSemantic proximity
Select a neighboring publication to make it the new centre.