Article
A Novel Mapping Strategy Utilizing Mouse Chromosome Substitution Strains Identifies Multiple Epistatic Interactions That Regulate Complex Traits.
G3 (Bethesda, Md.) - 3 Dec 2020
Miller Anna K, Chen Anlu, Bartlett Jacquelaine, Wang Li, Williams Scott M, Buchner David A
Abstract excerpt
The genetic contribution of additive vs. non-additive (epistatic) effects in the regulation of complex traits is unclear. While genome-wide association studies typically ignore gene-gene interactions, in part because of the lack of statistical power for detecting them, mouse chromosome substitution strains (CSSs) represent an alternate approach for detecting epistasis given their limited allelic variation....
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