Article

Concordance between male- and female-specific GWAS results helps define underlying genetic architecture of complex traits

2022-09-28

Abstract excerpt

A better understanding of genetic architecture will help translate genetic data into improved precision-based medicine and clinical care. Towards this end, we explored the use of sex-stratified analyses for several traits in the Hybrid Mouse Diversity Panel (HMDP) and UK Biobank to better determine trait polygenicity and identify contributing loci. This was accomplished by comparing the direction of allelic effect...

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Literature Corpus work: dff39088-1ac8-5822-9c16-0069b214390a
DOI: 10.1101/2022.09.28.509932

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