Back to search

Article

GXwasR: A Toolkit for Investigating Sex-Differentiated Genetic Effects on Complex Traits

2025-06-11

Abstract excerpt

Many complex traits in humans exhibit sex differences. Recent advances in understanding context-specific genetic effects underscore the imperative for sex-aware genetic analyses to assess the role of sex in the genetic basis of human phenotypes. Despite increasing recognition of the importance of sex as a biological variable, current computational tools for genome-wide association studies (GWAS) lack functionality...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d20d086c-bce4-5373-b490-7326e58832ee
DOI
10.1101/2025.06.10.25329327
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
GXwasR: A Toolkit for Investigating Sex-Differentiated Genetic Effects on Complex TraitsDOI 10.1101/2025.06.10.25329327
Evidence for sex-specific genetic architectures across a spectrum of human complex traits.Semantic proximity
Sex differences in genetic architecture in the UK Biobank.Semantic proximity
Sexual differences in genetic architecture in UK BiobankSemantic proximity
Meta-analysis of sex-specific genome-wide association studies.Semantic proximity
geneXplore: An Interactive Browser for X Chromosome-Wide Association Study ResultsSemantic proximity
Quality control and analytic best practices for testing genetic models of sex differences in large populations.Semantic proximity
XWAS: a software toolset for genetic data analysis and association studies of the X chromosomeSemantic proximity
How to include chromosome X in your genome-wide association study.Semantic proximity
XWAS: A Software Toolset for Genetic Data Analysis and Association Studies of the X Chromosome.Semantic proximity
Identifying sex-specific genetic effects across 733 traits in UK BiobankSemantic proximity
Concordance between male- and female-specific GWAS results helps define underlying genetic architecture of complex traits.Semantic proximity
Widespread and Biologically Driven Sex Disparities in Polygenic Risk Prediction Across Complex TraitsSemantic proximity
Select a neighboring publication to make it the new centre.