Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic factors contributing to extensive variability of sex-specific hepatic gene expression in Diversity Outbred mice.

PloS one - 1 Jan 2020

Melia Tisha, Waxman David J

Abstract excerpt

Sex-specific transcription characterizes hundreds of genes in mouse liver, many implicated in sex-differential drug and lipid metabolism and disease susceptibility. While the regulation of liver sex differences by growth hormone-activated STAT5 is well established, little is known about autosomal genetic factors regulating the sex-specific liver transcriptome. Here we show, using genotyping and expression data...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Mammalian
Share to Growth Hormone
Share to INDEL Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multigene Family

Share to Quantitative Trait Loci

Share to Regulatory Sequences, Nucleic Acid

Share to Sex Characteristics

Source

Open in PubMed Open full text

Identifiers

PMID: 33264334
DOI: 10.1371/journal.pone.0242665
PMCID: PMC7710091

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic factors contributing to extensive variability of sex-specific hepatic gene expression in Diversity Outbred mice.PMID 33264334Read ↗

Genetic factors contributing to extensive variability of sex-specific hepatic gene expression in Diversity Outbred miceSemantic proximity Read ↗

Harnessing natural variation to identify cis regulators of sex-biased gene expression in a multi-strain mouse liver model.Semantic proximity Read ↗

Harnessing natural variation to identify <i>cis</i> regulators of sex-biased gene expression in a multi-strain mouse liver modelSemantic proximity Read ↗

Sex-biased long non-coding RNAs negatively correlated with sex-opposite protein coding gene co-expression networks in Diversity Outbred mouse liverSemantic proximity Read ↗

Transcriptional Profiling of Human Liver Identifies Sex-Biased Genes Associated with Polygenic Dyslipidemia and Coronary Artery DiseaseSemantic proximity Read ↗

Sexual Dimorphism in Gene Expression: A Genome-Wide Study of Tissue and Chromosome DependenciesSemantic proximity Read ↗

Sexual Dimorphism in Gene Expression: A Multi-Tissue Genome-Wide Study in BXD Mice and Potential Insights into Human BiologySemantic proximity Read ↗

Sex-specific gene expression in the BXD mouse liverSemantic proximity Read ↗

Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity.Semantic proximity Read ↗

Analysis of sex differential genes at whole genome level reveals their organ-and chromosome-dependent expressions, regulations, and interactionsSemantic proximity Read ↗

Relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in tissue gene regulationSemantic proximity Read ↗

Dynamic, Sex-Differential STAT5 and BCL6 Binding to Sex-Biased, Growth Hormone-Regulated Genes in Adult Mouse LiverSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.