Article
Genotypic and functional impact of HIV-1 adaptation to its host population during the North American epidemic.
PLoS genetics - 1 Apr 2014
Cotton Laura A, Kuang Xiaomei T, Le Anh Q, Carlson Jonathan M, Chan Benjamin, Chopera Denis R, Brumme Chanson J, Markle Tristan J, Martin Eric, Shahid Aniqa, Anmole Gursev, Mwimanzi Philip, Nassab Pauline, Penney Kali A, Rahman Manal A, Milloy M-J, Schechter Martin T, Markowitz Martin, Carrington Mary, Walker Bruce D, Wagner Theresa, Buchbinder Susan, Fuchs Jonathan, Koblin Beryl, Mayer Kenneth H, Harrigan P Richard, Brockman Mark A, Poon Art F Y, Brumme Zabrina L
Abstract excerpt
HLA-restricted immune escape mutations that persist following HIV transmission could gradually spread through the viral population, thereby compromising host antiviral immunity as the epidemic progresses. To assess the extent and phenotypic impact of this phenomenon in an immunogenetically diverse population, we genotypically and functionally compared linked HLA and HIV (Gag/Nef) sequences from 358 historic...
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