Article
Extensive host immune adaptation in a concentrated North American HIV epidemic.
AIDS (London, England) - 10 Sept 2018
Brumme Zabrina L, Kinloch Natalie N, Sanche Stephen, Wong Alexander, Martin Eric, Cobarrubias Kyle D, Sandstrom Paul, Levett Paul N, Harrigan P Richard, Joy Jeffrey B
Abstract excerpt
OBJECTIVE: HIV incidence in the Canadian province of Saskatchewan, where Indigenous persons make up 80% of those infected, are among the highest on the continent. Reports of accelerated HIV progression, associated with carriage of certain human leukocyte antigen (HLA) alleles (including the typically protective HLA-B*51) have also emerged from the region. Given that acquisition of HIV preadapted to host HLA...
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