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Article

Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1.

Journal of virology - 1 Dec 2012

Carlson Jonathan M, Brumme Chanson J, Martin Eric, Listgarten Jennifer, Brockman Mark A, Le Anh Q, Chui Celia K S, Cotton Laura A, Knapp David J H F, Riddler Sharon A, Haubrich Richard, Nelson George, Pfeifer Nico, Deziel Charles E, Heckerman David, Apps Richard, Carrington Mary, Mallal Simon, Harrigan P Richard, John Mina, Brumme Zabrina L

Abstract excerpt

HLA class I-associated polymorphisms identified at the population level mark viral sites under immune pressure by individual HLA alleles. As such, analysis of their distribution, frequency, location, statistical strength, sequence conservation, and other properties offers a unique perspective from which to identify correlates of protective cellular immunity. We analyzed HLA-associated HIV-1 subtype B...

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Identifiers

PMID: 23055555
DOI: 10.1128/JVI.01998-12
PMCID: PMC3503140

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