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Article

Weaker HLA Footprints on HIV in the Unique and Highly Genetically Admixed Host Population of Mexico.

Journal of virology - 15 Jan 2018

Soto-Nava Maribel, Avila-Ríos Santiago, Valenzuela-Ponce Humberto, García-Morales Claudia, Carlson Jonathan M, Tapia-Trejo Daniela, Garrido-Rodriguez Daniela, Alva-Hernández Selma N, García-Tellez Thalía A, Murakami-Ogasawara Akio, Mallal Simon A, John Mina, Brockman Mark A, Brumme Chanson J, Brumme Zabrina L, Reyes-Teran Gustavo

Abstract excerpt

HIV circumvents HLA class I-restricted CD8+ T-cell responses through selection of escape mutations that leave characteristic mutational "footprints," also known as HLA-associated polymorphisms (HAPs), on HIV sequences at the population level. While many HLA footprints are universal across HIV subtypes and human populations, others can be region specific as a result of the unique immunogenetic background of each...

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Identifiers

PMID: 29093100
DOI: 10.1128/JVI.01128-17
PMCID: PMC5752930

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Source receipt: pubmed, retrieved 5 Sept 2026.

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