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Article

Population-Level Immune-Mediated Adaptation in HIV-1 Polymerase during the North American Epidemic.

Journal of virology - 1 Feb 2016

Kinloch Natalie N, MacMillan Daniel R, Le Anh Q, Cotton Laura A, Bangsberg David R, Buchbinder Susan, Carrington Mary, Fuchs Jonathan, Harrigan P Richard, Koblin Beryl, Kushel Margot, Markowitz Martin, Mayer Kenneth, Milloy M J, Schechter Martin T, Wagner Theresa, Walker Bruce D, Carlson Jonathan M, Poon Art F Y, Brumme Zabrina L

Abstract excerpt

UNLABELLED: Human leukocyte antigen (HLA) class I-associated polymorphisms in HIV-1 that persist upon transmission to HLA-mismatched hosts may spread in the population as the epidemic progresses. Transmission of HIV-1 sequences containing such adaptations may undermine cellular immune responses to the incoming virus in future hosts. Building upon previous work, we investigated the extent of HLA-associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Histocompatibility Antigens Class I

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Share to pol Gene Products, Human Immunodeficiency Virus

Source

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Identifiers

PMID: 26559841
DOI: 10.1128/JVI.02353-15
PMCID: PMC4719594

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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