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Article

Translation of HLA-HIV associations to the cellular level: HIV adapts to inflate CD8 T cell responses against Nef and HLA-adapted variant epitopes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2011

Almeida Coral-Ann M, Bronke Corine, Roberts Steven G, McKinnon Elizabeth, Keane Niamh M, Chopra Abha, Kadie Carl, Carlson Jonathan, Haas David W, Riddler Sharon A, Haubrich Richard, Heckerman David, Mallal Simon, John Mina

Abstract excerpt

Strong statistical associations between polymorphisms in HIV-1 population sequences and carriage of HLA class I alleles have been widely used to identify possible sites of CD8 T cell immune selection in vivo. However, there have been few attempts to prospectively and systematically test these genetic hypotheses arising from population-based studies at a cellular, functional level. We assayed CD8 T cell...

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Share to CD8-Positive T-Lymphocytes
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Infections

Share to HLA Antigens

Share to Immune Evasion

Share to Interferon-gamma

Share to nef Gene Products, Human Immunodeficiency Virus

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Source

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Identifiers

PMID: 21821798
DOI: 10.4049/jimmunol.1100691
PMCID: PMC3183574

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