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Article

Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level.

Science (New York, N.Y.) - 24 May 2002

Moore Corey B, John Mina, James Ian R, Christiansen Frank T, Witt Campbell S, Mallal Simon A

Abstract excerpt

Antigen-specific T cell immunity is HLA-restricted. Human immunodeficiency virus-type 1 (HIV-1) mutations that allow escape from host immune responses may therefore be HLA allele-specific. We analyzed HIV-1 reverse transcriptase sequences from a large HLA-diverse population of HIV-1-infected individuals. Polymorphisms in HIV-1 were most evident at sites of least functional or structural constraint and frequently...

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Share to Consensus Sequence
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, MHC Class I

Share to HIV Reverse Transcriptase

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Share to HLA-B Antigens

Share to T-Lymphocytes, Cytotoxic

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Source

Identifiers

PMID: 12029127
DOI: 10.1126/science.1069660

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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