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Article

Rapid HIV-1 Disease Progression in Individuals Infected with a Virus Adapted to Its Host Population.

PloS one - 1 Jan 2016

Katoh Jiro, Kawana-Tachikawa Ai, Shimizu Akihisa, Zhu Dayong, Han Chungyong, Nakamura Hitomi, Koga Michiko, Kikuchi Tadashi, Adachi Eisuke, Koibuchi Tomohiko, Gao George F, Brumme Zabrina L, Iwamoto Aikichi

Abstract excerpt

HIV-1 escape from CTL is predictable based on the Human Leukocyte Antigen (HLA) class I alleles expressed by the host. As such, HIV-1 sequences circulating in a population of hosts will harbor escape mutations specific to the HLA alleles of that population. In theory, this should increase the frequency of escape mutation transmission to persons expressing the restricting HLA allele, thereby compromising host...

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Share to Antigen Presentation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4 Lymphocyte Count

Share to Histocompatibility Antigens Class I

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Share to nef Gene Products, Human Immunodeficiency Virus

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Source

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Identifiers

PMID: 26953793
DOI: 10.1371/journal.pone.0150397
PMCID: PMC4783116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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