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Article

HIV-1 adaptation to HLA: a window into virus-host immune interactions.

Trends in microbiology - 1 Apr 2015

Carlson Jonathan M, Le Anh Q, Shahid Aniqa, Brumme Zabrina L

Abstract excerpt

HIV-1 develops specific mutations within its genome that allow it to escape detection by human leukocyte antigen (HLA) class I-restricted immune responses, notably those of CD8(+) cytotoxic T lymphocytes (CTL). HLA thus represents a major force driving the evolution and diversification of HIV-1 within individuals and at the population level. Importantly, the study of HIV-1 adaptation to HLA also represents an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

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Source

Identifiers

PMID: 25613992
DOI: 10.1016/j.tim.2014.12.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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