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Article

The impact of accumulating immune adaptation in circulating strains of HIV-1.

HIV medicine - 1 Jun 2026

Al-Kaabi Marwah, Castley Alison, Deshpande Pooja, Chopra Abha, Nolan David, Mallal Simon, John Mina, Gaudieri Silvana

Abstract excerpt

BACKGROUND: Mutations in human immunodeficiency virus type 1 (HIV-1) enable the virus to evade recognition and killing by human leucocyte antigen (HLA)-restricted T cells. These viral adaptations are specific to the HLA type of individuals and are therefore evident as HLA allele-HIV sequence associations at the population level. Most studies of HLA associations have been cross-sectional and may not capture...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41795223
DOI: 10.1111/hiv.70215

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