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Article

Multisite phosphorylation of the Sum1 transcriptional repressor by S-phase kinases controls exit from meiotic prophase in yeast.

Molecular and cellular biology - 1 Jun 2014

Corbi Daniel, Sunder Sham, Weinreich Michael, Skokotas Aikaterini, Johnson Erica S, Winter Edward

Abstract excerpt

Activation of the meiotic transcription factor Ndt80 is a key regulatory transition in the life cycle of Saccharomyces cerevisiae because it triggers exit from pachytene and entry into meiosis. The NDT80 promoter is held inactive by a complex containing the DNA-binding protein Sum1 and the histone deacetylase Hst1. Meiosis-specific phosphorylation of Sum1 by the protein kinases Cdk1, Ime2, and Cdc7 is required...

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Identifiers

PMID: 24710277
DOI: 10.1128/MCB.01413-13
PMCID: PMC4054303

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Multisite phosphorylation of the Sum1 transcriptional repressor by S-phase kinases controls exit from meiotic prophase in yeast.PMID 24710277Read ↗

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