Article
Timing of transcriptional quiescence during gametogenesis is controlled by global histone H3K4 demethylation.
Developmental cell - 13 Nov 2012
Xu Mengshu, Soloveychik Maria, Ranger Mathieu, Schertzberg Michael, Shah Zarna, Raisner Ryan, Venkatasubrahmanyan Shivkumar, Tsui Kyle, Gebbia Marinella, Hughes Tim, van Bakel Harm, Nislow Corey, Madhani Hiten D, Meneghini Marc D
Abstract excerpt
Gametes are among the most highly specialized cells produced during development. Although gametogenesis culminates in transcriptional quiescence in plants and animals, regulatory mechanisms controlling this are unknown. Here, we confirm that gamete differentiation in the single-celled yeast Saccharomyces cerevisiae is accompanied by global transcriptional shutoff following the completion of meiosis. We show that...
Topics
- Epigenesis, Genetic
- Gametogenesis
- Genes, Fungal
- Histones
- Jumonji Domain-Containing Histone Demethylases
- Meiosis
- Methylation
- Mutation
- Nucleosomes
- RNA, Fungal