Article
Polo-like kinase Cdc5 drives exit from pachytene during budding yeast meiosis.
Genes & development - 1 Oct 2008
Sourirajan Anuradha, Lichten Michael
Abstract excerpt
In budding yeast, exit from the pachytene stage of meiosis requires the mid-meiosis transcription factor Ndt80, which promotes expression of approximately 200 genes. Ndt80 is required for meiotic function of polo-like kinase (PLK, Cdc5) and cyclin-dependent kinase (CDK), two cell cycle kinases previously implicated in pachytene exit. We show that ongoing CDK activity is dispensable for two events that accompany...
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