Article
Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2.
Genes & development - 15 Jun 2003
Benjamin Kirsten R, Zhang Chao, Shokat Kevan M, Herskowitz Ira
Abstract excerpt
Meiosis is thought to require the protein kinase Ime2 early for DNA replication and the cyclin-dependent kinase Cdc28 late for chromosome segregation. To elucidate the roles of these kinases, we inhibited their activities early and late using conditional mutants that are sensitive to chemical inhibitors. Our studies reveal that both Cdc28 and Ime2 have critical roles in meiotic S phase and M phase. Early...
Topics
- CDC28 Protein Kinase, S cerevisiae
- Cell Cycle Proteins
- Cell Nucleus
- Cyclin-Dependent Kinase Inhibitor Proteins
- DNA-Binding Proteins
- Enzyme Inhibitors
- G1 Phase
- Intracellular Signaling Peptides and Proteins
- Meiosis
- Mitosis