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Article

The pachytene checkpoint in Saccharomyces cerevisiae requires the Sum1 transcriptional repressor.

The EMBO journal - 1 Dec 2000

Lindgren A, Bungard D, Pierce M, Xie J, Vershon A, Winter E

Abstract excerpt

Saccharomyces cerevisiae mutants that fail to complete meiotic recombination are blocked by the RAD17/RAD24/MEC1 checkpoint signaling pathway in pachytene when early sporulation genes are expressed. Middle genes are not activated in checkpoint-arrested cells because the Ndt80 transcription factor is inhibited. We find that the pachytene checkpoint requires Sum1, a transcriptional repressor that recognizes a...

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Source

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Identifiers

PMID: 11101521
DOI: 10.1093/emboj/19.23.6489
PMCID: PMC305847

Genes

RAD17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The pachytene checkpoint in Saccharomyces cerevisiae requires the Sum1 transcriptional repressor.PMID 11101521Read ↗

The Cdk1 and Ime2 protein kinases trigger exit from meiotic prophase in Saccharomyces cerevisiae by inhibiting the Sum1 transcriptional repressor.Semantic proximity Read ↗

Role of Ndt80, Sum1, and Swe1 as targets of the meiotic recombination checkpoint that control exit from pachytene and spore formation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Multisite phosphorylation of the Sum1 transcriptional repressor by S-phase kinases controls exit from meiotic prophase in yeast.Semantic proximity Read ↗

Sum1 and Ndt80 proteins compete for binding to middle sporulation element sequences that control meiotic gene expression.Semantic proximity Read ↗

The pachytene checkpoint.Semantic proximity Read ↗

Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice.Semantic proximity Read ↗

The pachytene checkpoint in S. cerevisiae depends on Swe1-mediated phosphorylation of the cyclin-dependent kinase Cdc28.Semantic proximity Read ↗

Combination of genomic approaches with functional genetic experiments reveals two modes of repression of yeast middle-phase meiosis genes.Semantic proximity Read ↗

Depletion of H2A-H2B dimers in Saccharomyces cerevisiae triggers meiotic arrest by reducing IME1 expression and activating the BUB2-dependent branch of the spindle checkpoint.Semantic proximity Read ↗

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