Article
The Cdk1 and Ime2 protein kinases trigger exit from meiotic prophase in Saccharomyces cerevisiae by inhibiting the Sum1 transcriptional repressor.
Molecular and cellular biology - 1 Jun 2010
Shin Marcus E, Skokotas Aikaterini, Winter Edward
Abstract excerpt
The induction of middle meiotic promoters is a key regulatory event in the life cycle of Saccharomyces cerevisiae that controls exit from prophase, meiosis, and spore formation. The Sum1 repressor and Ndt80 activator proteins control middle promoters by binding to overlapping DNA elements. NDT80 is controlled by a tightly regulated middle meiotic promoter through a positive autoregulatory loop and is repressed in...
Topics
- Binding Sites
- CDC2 Protein Kinase
- CDC28 Protein Kinase, S cerevisiae
- DNA-Binding Proteins
- Estradiol
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Intracellular Signaling Peptides and Proteins
- Meiotic Prophase I
- Mitogen-Activated Protein Kinases