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Article

Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae.

The EMBO journal - 15 Nov 1999

Xie J, Pierce M, Gailus-Durner V, Wagner M, Winter E, Vershon A K

Abstract excerpt

Meiotic development in yeast is characterized by the sequential induction of temporally distinct classes of genes. Genes that are induced at the middle stages of the pathway share a promoter element, termed the middle sporulation element (MSE), which interacts with the Ndt80 transcriptional activator. We have found that a subclass of MSEs are strong repressor sites during mitosis. SUM1 and HST1, genes previously...

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Identifiers

PMID: 10562556
DOI: 10.1093/emboj/18.22.6448
PMCID: PMC1171707

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae.PMID 10562556Read ↗

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Combination of genomic approaches with functional genetic experiments reveals two modes of repression of yeast middle-phase meiosis genes.Semantic proximity Read ↗

Regulation of the premiddle and middle phases of expression of the NDT80 gene during sporulation of Saccharomyces cerevisiae.Semantic proximity Read ↗

Multisite phosphorylation of the Sum1 transcriptional repressor by S-phase kinases controls exit from meiotic prophase in yeast.Semantic proximity Read ↗

The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program.Semantic proximity Read ↗

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Role of Ndt80, Sum1, and Swe1 as targets of the meiotic recombination checkpoint that control exit from pachytene and spore formation in Saccharomyces cerevisiae.Semantic proximity Read ↗

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