Article
Combination of genomic approaches with functional genetic experiments reveals two modes of repression of yeast middle-phase meiosis genes.
BMC genomics - 17 Aug 2010
Klutstein Michael, Siegfried Zahava, Gispan Ariel, Farkash-Amar Shlomit, Zinman Guy, Bar-Joseph Ziv, Simchen Giora, Simon Itamar
Abstract excerpt
BACKGROUND: Regulation of meiosis and sporulation in Saccharomyces cerevisiae is a model for a highly regulated developmental process. Meiosis middle phase transcriptional regulation is governed by two transcription factors: the activator Ndt80 and the repressor Sum1. It has been suggested that the competition between Ndt80 and Sum1 determines the temporal expression of their targets during middle meiosis....
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