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Article

A Mec1- and PP4-dependent checkpoint couples centromere pairing to meiotic recombination.

Developmental cell - 19 Oct 2010

Falk Jill E, Chan Andrew Chi-ho, Hoffmann Eva, Hochwagen Andreas

Abstract excerpt

The faithful alignment of homologous chromosomes during meiotic prophase requires the coordination of DNA double-strand break (DSB) repair with large-scale chromosome reorganization. Here we identify the phosphatase PP4 (Pph3/Psy2) as a mediator of this process in Saccharomyces cerevisiae. In pp4 mutants, early stages of crossover repair and homology-independent pairing of centromeres are coordinately blocked. We...

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Share to Centromere
Share to Chromosome Pairing
Share to Crossing Over, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

Share to Intracellular Signaling Peptides and Proteins

Share to Phosphoprotein Phosphatases

Share to Substrate Specificity

Share to Synaptonemal Complex

Source

Identifiers

PMID: 20951350
DOI: 10.1016/j.devcel.2010.09.006

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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