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Article

PDGF receptor signaling networks in normal and cancer cells

22 Mar 2014

Abstract excerpt

For about four decades, platelet-derived growth factors (PDGF) and their receptors have been the subject of intense research, revealing their roles in embryo development and human diseases. Drugs such as imatinib, which selectively inhibit the tyrosine kinase activity of these receptors, have been approved for the treatment of cancers such as gastrointestinal stromal tumors and chronic eosinophilic leukemia....

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PMID: 24703957
DOI: 10.1016/j.cytogfr.2014.03.003

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