Article
Role of platelet-derived growth factors in physiology and medicine.
Genes & development - 15 May 2008
Andrae Johanna, Gallini Radiosa, Betsholtz Christer
Abstract excerpt
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as prototypes for growth factor and receptor tyrosine kinase function for more than 25 years. Studies of PDGFs and PDGFRs in animal development have revealed roles for PDGFR-alpha signaling in gastrulation and in the development of the cranial and cardiac neural crest, gonads, lung, intestine, skin, CNS, and skeleton. Similarly,...
Topics
- Animals
- Bone and Bones
- Cardiovascular System
- Disease
- Embryo, Mammalian
- Embryonic Development
- Genetic Predisposition to Disease
- Humans
- Models, Biological
- Nervous System
- Organogenesis
- Platelet-Derived Growth Factor
- Polymorphism, Single Nucleotide
- Receptors, Platelet-Derived Growth Factor
- Receptors, Vascular Endothelial Growth Factor
- Signal Transduction
- Tissue Distribution
- Vascular Endothelial Growth Factor A