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Article

Roles of PDGF/PDGFR signaling in various organs

31 Oct 2024

Abstract excerpt

Platelet-derived growth factors (PDGFs) ligands and their corresponding receptors, PDGF receptor (PDGFR)α and PDGFRβ, play a crucial role in controlling diverse biological functions, including cell growth, viability and migration. These growth factors bind to PDGFRs, which are receptor tyrosine kinases present on the surface of target cells. The interaction between PDGFs and PDGFRs induces receptor dimerization...

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PMID: 39482238
DOI: 10.4196/kjpp.24.309

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