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Article

Autocrine PDGF stimulation in malignancies.

Upsala journal of medical sciences - 1 May 2012

Heldin Carl-Henrik

Abstract excerpt

Platelet-derived growth factor (PDGF) isoforms are important mitogens for different types of mesenchymal cells, which have important functions during the embryonal development and in the adult during wound healing and tissue homeostasis. In tumors, PDGF isoforms are often over-expressed and contribute to the growth of both normal and malignant cells. This review focuses on tumors expressing PDGF isoforms together...

Topics

Antineoplastic Agents
Humans
Mutation
Neoplasms
Oncogene Proteins v-sis
Platelet-Derived Growth Factor
Protein Isoforms
Receptors, Platelet-Derived Growth Factor

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 22512244
DOI: 10.3109/03009734.2012.658119
PMCID: PMC3339540

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