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Article

The PDGF/PDGFR pathway as a drug target.

Molecular aspects of medicine - 1 Aug 2018

Papadopoulos Natalia, Lennartsson Johan

Abstract excerpt

Platelet-derived growth factors (PDGF) promotes cell proliferation, survival and migration, primarily of cells of mesenchymal origin. Dysfunction of PDGF signaling has been observed in a wide array of pathological conditions, such as cancer, fibrosis, neurological conditions and atherosclerosis. Reported abnormalities of the PDGF pathway include overexpression or amplification of PDGF receptors (PDGFRs), gain of...

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Identifiers

PMID: 29137923
DOI: 10.1016/j.mam.2017.11.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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