Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New insights about the PDGF/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategies

13 Mar 2023

Abstract excerpt

Numerous cancers express platelet-derived growth factors (PDGFs) and PDGF receptors (PDGFRs). By directly stimulating tumour cells in an autocrine manner or by stimulating tumour stromal cells in a paracrine manner, the platelet-derived growth factor (PDGF)/platelet-derived growth factor receptor (PDGFR) pathway is crucial in the growth and spread of several cancers. To combat hypoxia in the tumour...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis and VEGF in Cancer
Share to Cancer, Hypoxia, and Metabolism
Share to Cytokine Signaling Pathways and Interactions

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37002577
DOI: 10.1016/j.biopha.2023.114491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New insights about the PDGF/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategiesPMID 37002577Read ↗

The PDGF/PDGFR pathway as a drug target.Semantic proximity Read ↗

Role of platelet-derived growth factors in physiology and medicine.Semantic proximity Read ↗

Autocrine PDGF stimulation in malignancies.Semantic proximity Read ↗

Roles of PDGF/PDGFR signaling in various organsSemantic proximity Read ↗

PDGF receptor signaling networks in normal and cancer cellsSemantic proximity Read ↗

Platelet-derived Growth Factor Signaling and Human CancerSemantic proximity Read ↗

PDGF receptors as targets in tumor treatment.Semantic proximity Read ↗

An overview of agents and treatments for PDGFRA-mutated gastrointestinal stromal tumorsSemantic proximity Read ↗

Targeting PDGF receptors in cancer--rationales and proof of concept clinical trials.Semantic proximity Read ↗

Oncogenic derivatives of platelet-derived growth factor receptors.Semantic proximity Read ↗

Functional and clinical roles of stromal PDGF receptors in tumor biologySemantic proximity Read ↗

PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.