Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Platelet-derived Growth Factor Signaling and Human Cancer

31 Jan 2003

Abstract excerpt

Platelet-derived growth factor (PDGF) is a critical regulator of mesenchymal cell migration and proliferation. The vital functions of PDGFs for angiogenesis, as well as development of kidney, brain, cardiovascular system and pulmonary alveoli during embryogenesis, have been well demonstrated by gene knock-out approaches. Clinical studies reveal that aberrant expression of PDGF and its receptor is often associated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Prostate Cancer Treatment and Research
Share to Pulmonary Hypertension Research and Treatments
Share to Venous Thromboembolism Diagnosis and Management

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12542975
DOI: 10.5483/bmbrep.2003.36.1.049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Platelet-derived Growth Factor Signaling and Human CancerPMID 12542975Read ↗

Role of platelet-derived growth factors in physiology and medicine.Semantic proximity Read ↗

PDGF receptor signaling networks in normal and cancer cellsSemantic proximity Read ↗

Roles of PDGF/PDGFR signaling in various organsSemantic proximity Read ↗

Autocrine PDGF stimulation in malignancies.Semantic proximity Read ↗

Functional and clinical roles of stromal PDGF receptors in tumor biologySemantic proximity Read ↗

Structural and functional specificities of PDGF‐C and PDGF‐D, the novel members of the platelet‐derived growth factors familySemantic proximity Read ↗

New insights about the PDGF/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategiesSemantic proximity Read ↗

PDGF-C and PDGF-D signaling in vascular diseases and animal models.Semantic proximity Read ↗

Oncogenic derivatives of platelet-derived growth factor receptors.Semantic proximity Read ↗

Evidence for distinct signaling properties and biological responses induced by the PDGF receptor alpha and beta subtypes.Semantic proximity Read ↗

Pathogenetic significance and possibility as a therapeutic target of platelet derived growth factorSemantic proximity Read ↗

PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.