Characteristics of the cation cotransporter NKCC1 in human brain: alternate transcripts, expression in development, and potential relationships to brain function and schizophrenia.

doi:10.1523/JNEUROSCI.1423-13.2014

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Article

Characteristics of the cation cotransporter NKCC1 in human brain: alternate transcripts, expression in development, and potential relationships to brain function and schizophrenia.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Apr 2014

Morita Yukitaka, Callicott Joseph H, Testa Lauren R, Mighdoll Michelle I, Dickinson Dwight, Chen Qiang, Tao Ran, Lipska Barbara K, Kolachana Bhaskar, Law Amanda J, Ye Tianzhang, Straub Richard E, Weinberger Daniel R, Kleinman Joel E, Hyde Thomas M

Abstract excerpt

Early in development, GABA, an inhibitory neurotransmitter in adults, is excitatory. NKCC1 (SLC12A2) encodes one of two cation chloride cotransporters mediating the conversion of GABA from excitatory to inhibitory. Using 3' and 5' RACE and PCR, we verified previously characterized alternative transcripts of NKCC1a (1-27) and NKCC1b (1-27(Δ21)), identified new NKCC1 transcripts, and explored their expression...

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PMID: 24695712
DOI: 10.1523/JNEUROSCI.1423-13.2014
PMCID: PMC3972720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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