Article
Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood.
Molecular psychiatry - 1 Mar 2018
Dedic N, Pöhlmann M L, Richter J S, Mehta D, Czamara D, Metzger M W, Dine J, Bedenk B T, Hartmann J, Wagner K V, Jurik A, Almli L M, Lori A, Moosmang S, Hofmann F, Wotjak C T, Rammes G, Eder M, Chen A, Ressler K J, Wurst W, Schmidt M V, Binder E B, Deussing J M
Abstract excerpt
Single-nucleotide polymorphisms (SNPs) in CACNA1C, the α1C subunit of the voltage-gated L-type calcium channel Cav1.2, rank among the most consistent and replicable genetics findings in psychiatry and have been associated with schizophrenia, bipolar disorder and major depression. However, genetic variants of complex diseases often only confer a marginal increase in disease risk, which is additionally influenced...
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