Article
A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia.
Nature medicine - 1 May 2009
Huffaker Stephen J, Chen Jingshan, Nicodemus Kristin K, Sambataro Fabio, Yang Feng, Mattay Venkata, Lipska Barbara K, Hyde Thomas M, Song Jian, Rujescu Dan, Giegling Ina, Mayilyan Karine, Proust Morgan J, Soghoyan Armen, Caforio Grazia, Callicott Joseph H, Bertolino Alessandro, Meyer-Lindenberg Andreas, Chang Jay, Ji Yuanyuan, Egan Michael F, Goldberg Terry E, Kleinman Joel E, Lu Bai, Weinberger Daniel R
Abstract excerpt
Organized neuronal firing is crucial for cortical processing and is disrupted in schizophrenia. Using rapid amplification of 5' complementary DNA ends in human brain, we identified a primate-specific isoform (3.1) of the ether-a-go-go-related K(+) channel KCNH2 that modulates neuronal firing. KCNH2-3.1 messenger RNA levels are comparable to full-length KCNH2 (1A) levels in brain but three orders of magnitude...
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