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NKCC1: Newly Found as a Human Disease-Causing Ion Transporter.

Function (Oxford, England) - 1 Jan 2021

Koumangoye Rainelli, Bastarache Lisa, Delpire Eric

Abstract excerpt

Among the electroneutral Na+-dependent chloride transporters, NKCC1 had until now evaded identification as a protein causing human diseases. The closely related SLC12A transporters, NKCC2 and NCC have been identified some 25 years ago as responsible for Bartter and Gitelman syndromes: two renal-dependent salt wasting disorders. Absence of disease was most surprising since the NKCC1 knockout mouse was shown in...

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PMID: 33345190
DOI: 10.1093/function/zqaa028
PMCID: PMC7727275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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