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Article

Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Jul 2011

Hyde Thomas M, Lipska Barbara K, Ali Towhid, Mathew Shiny V, Law Amanda J, Metitiri Ochuko E, Straub Richard E, Ye Tianzhang, Colantuoni Carlo, Herman Mary M, Bigelow Llewellyn B, Weinberger Daniel R, Kleinman Joel E

Abstract excerpt

GABA signaling molecules are critical for both human brain development and the pathophysiology of schizophrenia. We examined the expression of transcripts derived from three genes related to GABA signaling [GAD1 (GAD67 and GAD25), SLC12A2 (NKCC1), and SLC12A5 (KCC2)] in the prefrontal cortex (PFC) and hippocampal formation of a large cohort of nonpsychiatric control human brains (n = 240) across the lifespan...

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Identifiers

PMID: 21795557
DOI: 10.1523/JNEUROSCI.1234-11.2011
PMCID: PMC3758549

Genes

GAD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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