Article
Neuronal activity disrupts myelinated axon integrity in the absence of NKCC1b.
The Journal of cell biology - 6 Jul 2020
Marshall-Phelps Katy L H, Kegel Linde, Baraban Marion, Ruhwedel Torben, Almeida Rafael G, Rubio-Brotons Maria, Klingseisen Anna, Benito-Kwiecinski Silvia K, Early Jason J, Bin Jenea M, Suminaite Daumante, Livesey Matthew R, Möbius Wiebke, Poole Richard J, Lyons David A
Abstract excerpt
Through a genetic screen in zebrafish, we identified a mutant with disruption to myelin in both the CNS and PNS caused by a mutation in a previously uncharacterized gene, slc12a2b, predicted to encode a Na+, K+, and Cl- (NKCC) cotransporter, NKCC1b. slc12a2b/NKCC1b mutants exhibited a severe and progressive pathology in the PNS, characterized by dysmyelination and swelling of the periaxonal space at the...
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