Article
Allele-specific differences in activity of a novel cannabinoid receptor 1 (CNR1) gene intronic enhancer in hypothalamus, dorsal root ganglia, and hippocampus.
The Journal of biological chemistry - 13 Apr 2012
Nicoll Gemma, Davidson Scott, Shanley Lynne, Hing Ben, Lear Marissa, McGuffin Peter, Ross Ruth, MacKenzie Alasdair
Abstract excerpt
Polymorphisms within intron 2 of the CNR1 gene, which encodes cannabinoid receptor 1 (CB(1)), have been associated with addiction, obesity, and brain volume deficits. We used comparative genomics to identify a polymorphic (rs9444584-C/T) sequence (ECR1) in intron 2 of the CNR1 gene that had been conserved for 310 million years. The C-allele of ECR1 (ECR1(C)) acted as an enhancer in hypothalamic and dorsal root...
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