Article
Transcript-specific associations of SLC12A5 (KCC2) in human prefrontal cortex with development, schizophrenia, and affective disorders.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 Apr 2012
Tao Ran, Li Chao, Newburn Erin N, Ye Tianzhang, Lipska Barbara K, Herman Mary M, Weinberger Daniel R, Kleinman Joel E, Hyde Thomas M
Abstract excerpt
The neuron-specific K(+)-Cl(-) cotransporter SLC12A5, also known as KCC2, helps mediate the electrophysiological effects of GABA. The pattern of KCC2 expression during early brain development suggests that its upregulation drives the postsynaptic switch of GABA from excitation to inhibition. We previously found decreased expression of full-length KCC2 in the postmortem hippocampus of patients with schizophrenia,...
Topics
- Adult
- Aged, 80 and over
- Bipolar Disorder
- Blotting, Western
- Cell Line
- DNA, Complementary
- Depressive Disorder, Major
- Exons
- Female
- Gene Amplification