The Tau mutation of casein kinase 1ε sets the period of the mammalian pacemaker via regulation of Period1 or Period2 clock proteins.

doi:10.1177/0748730414520663

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The Tau mutation of casein kinase 1ε sets the period of the mammalian pacemaker via regulation of Period1 or Period2 clock proteins.

Journal of biological rhythms - 1 Apr 2014

Maywood E S, Chesham J E, Smyllie N J, Hastings M H

Abstract excerpt

The suprachiasmatic nucleus (SCN) of the hypothalamus is the principal circadian pacemaker in mammals, coordinating daily metabolic and physiological rhythms with the cycle of sleep and wakefulness. SCN neurons define circadian time via an auto-regulatory feedback loop in which the activation of Period (Per) and Cryptochrome genes is periodically suppressed by their own protein products. Casein kinase 1 (CK1)...

Topics

Animals
Casein Kinase 1 epsilon
Circadian Rhythm
Female
Humans
Light
Luciferases
Luminescent Measurements
Male
Mice
Mice, Knockout
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Motor Activity

Mutation

Neurons

Organ Culture Techniques

Period Circadian Proteins

Suprachiasmatic Nucleus

Source

Open in PubMed Open full text

Identifiers

PMID: 24682205
DOI: 10.1177/0748730414520663
PMCID: PMC4131702

Genes

PER1
PER2
PER3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24682205-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Tau mutation of casein kinase 1ε sets the period of the mammalian pacemaker via regulation of Period1 or Period2 clock proteins.PMID 24682205Read ↗

Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins.Semantic proximity Read ↗

The biology of the circadian Ck1epsilon tau mutation in mice and Syrian hamsters: a tale of two species.Semantic proximity Read ↗

Tuning the period of the mammalian circadian clock: additive and independent effects of CK1εTau and Fbxl3Afh mutations on mouse circadian behavior and molecular pacemaking.Semantic proximity Read ↗

Casein Kinase 1 and Human Disease: Insights From the Circadian PhosphoswitchSemantic proximity Read ↗

Casein Kinase 1 dynamics underlie the PER2 circadian phosphoswitchSemantic proximity Read ↗

Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch.Semantic proximity Read ↗

Dominant-negative CK2alpha induces potent effects on circadian rhythmicity.Semantic proximity Read ↗

Distinct functions of Period2 and Period3 in the mouse circadian system revealed by in vitro analysis.Semantic proximity Read ↗

Involvement of the protein kinase CK2 in the regulation of mammalian circadian rhythms.Semantic proximity Read ↗

An opposite role for tau in circadian rhythms revealed by mathematical modeling.Semantic proximity Read ↗

In vivo circadian function of casein kinase 2 phosphorylation sites in Drosophila PERIOD.Semantic proximity Read ↗

Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.