Article
An opposite role for tau in circadian rhythms revealed by mathematical modeling.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jul 2006
Gallego Monica, Eide Erik J, Woolf Margaret F, Virshup David M, Forger Daniel B
Abstract excerpt
Biological clocks with a period of approximately 24 h (circadian) exist in most organisms and time a variety of functions, including sleep-wake cycles, hormone release, bioluminescence, and core body temperature fluctuations. Much of our understanding of the clock mechanism comes from the identif...
Topics
- Animals
- Casein Kinase 1 epsilon
- Casein Kinase I
- Cell Cycle Proteins
- Cell Line
- Circadian Rhythm
- Humans
- Mice
- Models, Biological
- Mutation
- NIH 3T3 Cells
- Nuclear Proteins
- Period Circadian Proteins
- Phosphorylation
- Transcription Factors