Article
An opposite role for tau in circadian rhythms revealed by mathematical modeling.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jul 2006
Gallego Monica, Eide Erik J, Woolf Margaret F, Virshup David M, Forger Daniel B
Abstract excerpt
Biological clocks with a period of approximately 24 h (circadian) exist in most organisms and time a variety of functions, including sleep-wake cycles, hormone release, bioluminescence, and core body temperature fluctuations. Much of our understanding of the clock mechanism comes from the identification of specific mutations that affect circadian behavior. A widely studied mutation in casein kinase I (CKI), the...
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