Article
The biology of the circadian Ck1epsilon tau mutation in mice and Syrian hamsters: a tale of two species.
Cold Spring Harbor symposia on quantitative biology - 1 Jan 2007
Loudon A S I, Meng Q J, Maywood E S, Bechtold D A, Boot-Handford R P, Hastings M H
Abstract excerpt
The tau mutation in the Syrian hamster resides in the enzyme casein kinase 1 epsilon (CK1epsilon), resulting in a dramatic acceleration of wheel-running activity cycles to about 20 hours. tau also impacts growth, energy, metabolism, feeding behavior, and circadian mechanisms underpinning seasonal timing, causing accelerated reproductive and neuroendocrine responses to photoperiodic changes. Modeling and...
Topics
- Activity Cycles
- Animals
- CLOCK Proteins
- Casein Kinase 1 epsilon
- Circadian Rhythm
- Cricetinae
- Cryptochromes
- Female
- Flavoproteins
- Male
- Mesocricetus
- Mice
- Mice, Knockout
- Mice, Mutant Strains
- Models, Biological